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Numerical validation of a synthetic cell-based model of blood coagulation

Pavlova, Jevgenija; Janela, João; Sequeira, Adélia

Journal of Theoretical Biology, 380 (2015), 367-379

In [8] a new reduced mathematical model for blood oagulation was proposed, incorporating biochemical and mechanical actions of blood flow and including platelets activity. The model was characterized by a considerable simplification of the differential system associated to the biochemical network and it incorporated the role of blood slip at the
vessel wall as an extra source of activated platelets.
The purpose of this work is to check the validity of the reduced mathematical model, using as a benchmark the model presented in [1], and to investigate the importance of the blood slip velocity in the blood coagulation process.