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A model approach to understand blood-clotting dynamics

Pavlova, Jevgenija; Fasano, A.; Janela, João; Sequeira, Adélia

Proceedings of the 11th World Congress on Computational Mechanics (WCCM XI), 5th European Conference on Computational Mechanics (ECCM V), 6th European Conference on Computational Fluid Dynamics (ECFD VI), July 20-25, Barcelona, Spain, (2014),

The process of platelet activation and blood coagulation is very complex and not yet well understood. Experimental studies recognize that thrombus formation can occur within
blood vessels bifurcations, branching or strong curvature regions. Moreover, internal cardiovascular devices such as prosthetic heart valves, ventricular assist devices and stents foster high hemodynamic shear stresses that can cause platelet activation and clot formation. On the other hand, diseases due to dysfunctions of the hemostatic system are also of primary importance.

Knowing that laboratory experiments are usually very expensive and time consuming, an investment in comprehensive, reliable and easy to handle mathematical models can contribute to a better understanding of these complex phenomena [2-5].