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Numerical validation of a synthetic cell-based model for blood coagulation

Pavlova, Jevgenija; Fasano, A.; Janela, João; Sequeira, Adélia

A publicar em Journal of Theoretical Biology

In [8] a new reduced mathematical model for blood coagulation was proposed, incorporating biochemical and mechanical actions of blood flow and including platelets activity. The model was characterized by a considerable simplification of the differential system associated to the
biochemical network and it incorporated the role of blood slip at the vessel wall as an extra source of activated platelets.

The purpose of this work is to check the validity of the reduced mathematical model, using as a benchmark the model presented in [1], and to investigate the importance of the blood slip velocity in the blood coagulation process.